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five–four μmol/L range,[156][157] the concentration of serotonin in synaptic vesicles was calculated at 270 mM.[182] next vesicular release, the resulting concentration of serotonin from the synaptic cleft, to which serotonin receptors are uncovered, is believed to be about three hundred μmol/L. So, whilst in vitro receptor binding affinities
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